贾舒婷 副教授 硕士生导师

E-mail：shutingjia@kust.edu.cn

教育经历

2002.9-2006.7 青岛大学 学士

2006.9-2012.5 昆明理工大学 博士

工作经历

2012-2015  昆明理工大学医学院 讲师

2017-2018  耶鲁大学医学院 访问学者

2016-至今  昆明理工大学医学院 副教授

研究方向

p53突变的功能获得，端粒在衰老和肿瘤中的作用，端粒延长替代机制（ALT）。

科研基金

(1)云南省科技厅，重点项目，项目编号：202201AS070074，基于ALT肿瘤小鼠模型和网络药理学的端粒酶阴性肿瘤靶向药物筛选及其作用机制研究，2022-06至2025-05，50万元，主持。

(2) 云南省人才工作小组办公室，云南省“兴滇英才支持计划”入选者, 项目编号：YNWR-QNBJ-2019-240, 突变p53N236S对DNA修复及端粒功能维持的调控机制研究， 2020-01 至 2024-12, 50万元， 在研， 主持

(3) 云南省科技厅，面上项目， 项目编号：2019FB109，p53N236S突变协同Ras原癌基因耐受阿霉素诱导的凋亡机制研究, 2019-07 至 2022-06, 10万元, 在研, 主持

(4) 国家自然科学基金委员会, 地区科学基金项目, 项目编号：81760262, p53N236S突变在细胞逃逸Ras癌基因诱导衰老中的作用机制研究, 2018-01-01 至 2021-12-31, 34万元, 结题, 主持

(5) 国家自然科学基金委员会，地区基金项目，项目编号：81460457，p53N236S获得耐药表型的分子机制研究，2015-01至2018-12，47万元，结题，主持

代表性论文

(1) Hou, Kailong; Yu, Yuyang; Li, Duda; Zhang, Yanduo; Zhang, Ke; Tong, Jinkai; Yang,Kunxian*; Jia, Shuting*. Alternative Lengthening of Telomeres and Mediated Telomere Synthesis. Cancers (Basel) 2022; 14

(2) Gao, Kang; Zong, Huanhuan; Hou, Kailong; Zhang, Yanduo; Zhang, Ruyi; Zhao, Dan; Guo, Xin; Luo, Ying; Jia, Shuting*. p53N236S Activates Autophagy in Response to Hypoxic Stress Induced by DFO. Genes (Basel) 2022; 13.

(3) Li, Duda; Hou, Kailong; Zhang, Ke; Jia, Shuting*; Regulation of Replication Stress in Alternative Lengthening of Telomeres by Fanconi Anaemia Protein, Genes, 2022, 13(2)

(4) Gu, Peili; Jia, Shuting; Takasugi, Taylor; Tesmer, Valerie M; Nandakumar, Jayakrishnan; Chen, Yong; Chang, Sandy. Distinct functions of POT1 proteins contribute to the regulation of telomerase recruitment to telomeres. Nat Commun 2021; 12: 5514

(5) 余雨杨; 侯凯龙; 仝津凯; 张艳多; 贾舒婷*. 有丝分裂期DNA合成(MiDAS)及其介导的端粒复制，生物化学与生物物理进展, 2022

(6) Gu, Peili; Jia, Shuting; Takasugi, Taylor; Tesmer, Valerie M.; Nandakumar, Jayakrishnan;Chen, Yong; Chang, Sandy ; Distinct functions of POT1 proteins contribute to the regulation of telomerase recruitment to telomeres, Nature Communications, 2021, 12(1): 0-5514

(7) 宗欢欢; 侯凯龙; 郭鑫; 罗瑛; 贾舒婷*. 端粒结合蛋白在端粒复制与损伤修复中的作用, 生物化学与生物物理进展, 2021, 48(12): 1448-1455

(8) Gu, Peili; Jia, Shuting; Takasugi, Taylor; Smith, Eric; Nandakumar, Jayakrishnan; Hendrickson, Eric; Chang, Sandy ; CTC1-STN1 coordinates G- and C-strand synthesis to regulate telomere length, AGING CELL, 2018, 17(4): 0-UNSP e12783

(9) Zhao, Lanjun; Wang, Boyuan; Zhao, Xilong; Wu, Xiaoming; Zhang, Qiushi; Wei, Chuanyu; Shi, Minling; Li, Yunlong; Tang, Wenru; Zhang, Jihong; Yang, Julun; Singh, Sanjay K; Jia, Shuting*; Luo, Ying*; Gain of function in the mouse model of a recurrent mutation p53(N236S) promotes the formation of double minute chromosomes and the oncogenic potential of p19(ARF), Molecular Carcinogenesis, 2018, 57(2): 147-158

(10) Jia, Shuting; Zhao, Lanjun; Tang, Wenru; Luo, Ying*, The Gain of Function of p53 Mutant p53S in Promoting Tumorigenesis by Cross-talking with H-RasV12, International Journal of Biological Sciences, 2012, 8(5): 596-605.

(11) Wu, Xiaoming1; Jia, Shuting1; Zhang, Xiufeng; Si, Xiaoyu; Tang, Wenru; Luo, Ying.* Two mechanisms underlying the loss of p16(Ink4a) function are associated with distinct tumorigenic consequences for WS MEFs escaping from senescence. Mechanisms of Ageing and Development,  2012, 33(8):549-55. (1 These authors contributed equally to the work)

(12) Zhao Lanjun; Jia Shuting; Tang Wenru; Sheng Jun; Luo Ying*; Pu-erh Tea Inhibits Tumor Cell Growth by Down-Regulating Mutant p53, International Journal of Molecular Sciences, 2011, 12(11): 7581-7593.